Effects of alcohol on the composition and metabolism of the intestinal microbiota among people with HIV: A cross-sectional study.

ABSTRACT:

Objectives

Alcohol consumption is not uncommon among people with HIV (PWH) and may exacerbate HIV-induced intestinal damage, and further lead to dysbiosis and increased intestinal permeability. This study aimed to determine the changes in the fecal microbiota and its association with alcohol consumption in HIV-infected patients.

Methods

A cross-sectional survey was conducted between November 2021 and May 2022, and 93 participants were recruited. To investigate the alterations of alcohol misuse on fecal microbiology in HIV-infected individuals, we performed 16s rDNA gene sequencing on fecal samples from the low-to-moderate drinking (n = 21) and non-drinking (n = 72) groups.

Results

Comparison between groups using alpha and beta diversity showed that the diversity of st

SUBMITTER: Qiao NN 

PROVIDER: S-EPMC11383188 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature