Virulence gene polymorphisms in Shandong Helicobacter pylori strains and their relevance to gastric cancer.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) virulence factors, particularly the cagA and vacA genotypes, play important roles in the pathogenic process of gastrointestinal disease.

Methods

The cagA and vacA genotypes of 87 H. pylori strains were determined by PCR and sequencing. The EPIYA and CM motif patterns were analyzed and related to clinical outcomes. We examined the associations between the virulence genes of H. pylori and gastrointestinal diseases in Shandong, and the results were analyzed via the chi-square test and logistic regression model.

Results

Overall, 76 (87.36%) of the strains carried the East Asian-type CagA, with the ABD types being the most prevalent (90.79%). However, no significant differences were observed among the different clinical outcomes.

SUBMITTER: Xue Z 

PROVIDER: S-EPMC11383249 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature