Differential encoding of mammalian proprioception by voltage-gated sodium channels.

ABSTRACT: Animals that require purposeful movement for survival are endowed with mechanosensory neurons called proprioceptors that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of proprioceptive signaling in daily life, the mechanisms governing proprioceptor activity are poorly understood. Here, we have identified distinct and nonredundant roles for two voltage-gated sodium channels (Na_Vs), Na_V1.1 and Na_V1.6, in mammalian proprioception. Deletion of Na_V1.6 in somatosensory neurons (Na_V1.6^cKO mice) causes severe motor deficits accompanied by complete loss of proprioceptive transmission, which contrasts with our previous findings using simil

SUBMITTER: Espino CM 

PROVIDER: S-EPMC11383322 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature