Intraepithelial CD15 infiltration identifies high-grade anal dysplasia in people with HIV.

ABSTRACT: Men who have sex with men (MSM) with HIV are at high risk for squamous intraepithelial lesion (SIL) and anal cancer. Identifying local immunological mechanisms involved in the development of anal dysplasia could aid treatment and diagnostics. Here, we studied 111 anal biopsies obtained from 101 MSM with HIV, who participated in an anal screening program. We first assessed multiple immune subsets by flow cytometry, in addition to histological examination, in a discovery cohort. Selected molecules were further evaluated by immunohistochemistry in a validation cohort. Pathological samples were characterized by the presence of resident memory T cells with low expression of CD103 and by changes in natural killer cell subsets, affecting residency and activation. Furthermore, potentially immunosu

SUBMITTER: Burgos J 

PROVIDER: S-EPMC11383605 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature