Regulatory network analysis of <i>Dclk1</i> gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression.

ABSTRACT: Dclk1 expression defines a rare population of cells in the normal pancreas whose frequency is increased at early stages of pancreatic tumorigenesis. The identity and the precise roles of Dclk1 expressing cells in pancreas have been matter of debate, although evidence suggests their involvement in a number of key functions, including regeneration and neoplasia. We employed a recently developed Dclk1 reporter mouse model and single cell RNAseq analysis to define Dclk1 expressing cells in normal pancreas and pancreatic neoplasia. In normal pancreas, Dclk1 epithelial expression identifies subsets of ductal, islet and acinar cells. In pancreatic neoplasia, Dclk1 expression identifies five epithelial cell populations, among which acinar-to-ductal metaplasia (AD

SUBMITTER: Valenti G 

PROVIDER: S-EPMC11383664 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature