Decrypting the phylogenetics history of EGF-CFC proteins Cripto and Cryptic.

ABSTRACT: EGF-CFC proteins are obligate coreceptors for Nodal signaling and are thus required for gastrulation and left-right patterning. Species with multiple family members show evidence of specialization. For example, mouse Cripto is required for gastrulation, whereas Cryptic is involved in left-right patterning. However, the members of the family across model organisms have little sequence conservation beyond the EGF-CFC domain, posing challenges for determining their evolutionary history and functional conservation. In this study we outline the evolutionary history of the EGF-CFC family of proteins. We traced the EGF-CFC gene family from a single gene in the deuterostome ancestor through its expansion and functional specialization in tetrapods, and subsequent gene loss and

SUBMITTER: Shylo NA 

PROVIDER: S-EPMC11383694 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature