Extensive transmission and variation in a functional receptor for praziquantel resistance in endemic Schistosoma mansoni.

ABSTRACT: Mass-drug administration (MDA) of human populations using praziquantel monotherapy has become the primary strategy for controlling and potentially eliminating the major neglected tropical disease schistosomiasis. To understand how long-term MDA impacts schistosome populations, we analysed whole-genome sequence data of 570 Schistosoma mansoni samples (and the closely related outgroup species, S. rodhaini) from eight countries incorporating both publicly-available sequence data and new parasite material. This revealed broad-scale genetic structure across countries but with extensive transmission over hundreds of kilometres. We characterised variation across the transient receptor potential melastatin ion channel, TRPM_PZQ, a target of praziquantel, which has recently

SUBMITTER: Berger DJ 

PROVIDER: S-EPMC11383708 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature