Disruptions in antigen processing and presentation machinery on sarcoma.

ABSTRACT:

Background

The antigen processing machinery (APM) plays a critical role in generating tumor-specific antigens that can be recognized and targeted by the immune system. Proper functioning of APM components is essential for presenting these antigens on the surface of tumor cells, enabling immune detection and destruction. In many cancers, defects in APM can lead to immune evasion, contributing to tumor progression and poor clinical outcomes. However, the status of the APM in sarcomas is not well characterized, limiting the development of effective immunotherapeutic strategies for these patients.

Methods

We investigated 126 patients with 8 types of bone and soft tissue sarcoma operated between 2001-2021. Tissue microarrays mapped 11 specific areas in each case. The presence/abs

SUBMITTER: Renne SL 

PROVIDER: S-EPMC11383888 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature