Epitranscriptomic regulation of lipid oxidation and liver fibrosis via ENPP1 mRNA m⁶A modification.

ABSTRACT:

Background

Dysregulated lipid oxidation occurs in several pathological processes characterized by cell proliferation and migration. Nonetheless, the molecular mechanism of lipid oxidation is not well appreciated in liver fibrosis, which is accompanied by enhanced fibroblast proliferation and migration.

Methods

We investigated the causes and consequences of lipid oxidation in liver fibrosis using cultured cells, animal models, and clinical samples.

Results

Increased ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP1) expression caused increased lipid oxidation, resulting in the proliferation and migration of hepatic stellate cells (HSCs) that lead to liver fibrosis, whereas fibroblast-specific ENPP1 knockout reversing these results. Elevated ENPP1 and N⁶

SUBMITTER: Sun F 

PROVIDER: S-EPMC11383905 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature