Electroencephalography-based endogenous phenotype of diagnostic transition from major depressive disorder to bipolar disorder.

ABSTRACT: The neuropathology of mood disorders, including the diagnostic transition from major depressive disorder (MDD) to bipolar disorder (BD), is poorly understood. This study investigated resting-state electroencephalography (EEG) activity in patients with MDD and those whose diagnosis changed from MDD to BD. Among sixty-eight enrolled patients with MDD, the diagnosis of 17 patients converted to BD during the study period. We applied machine learning techniques to differentiate the two groups using sensor- and source-level EEG features. At the sensor level, patients with BD showed higher theta band power at the AF3 channel and low-alpha band power at the FC5 channel compared to patients with MDD. At the source level, patients with BD showed higher theta band activity in the right anterior cingu

SUBMITTER: Jang KI 

PROVIDER: S-EPMC11383931 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature