Longitudinal mapping of cortical change during early adolescence associated with prenatal tobacco and/or alcohol exposure in the Adolescent Brain Cognitive Development Study.

ABSTRACT:

Importance

The effects of prenatal alcohol (PAE) and tobacco exposure (PTE) on adolescent neuroanatomical development are typically evaluated cross-sectionally. It is unclear if observed effects persist throughout life or reflect different developmental trajectories.

Objective

To determine how PAE and PTE are associated with cortical structure and development across two timepoints in early adolescence.

Design

Observational, longitudinal analyses of data within the Adolescent Brain Cognitive Development Study.

Setting

21 study sites in the United States.

Participants

5,417 youth participants, aged ~9-12 years old.

Exposures

PAE and PTE based on caregiver (self) reports of alcohol/tobacco use during pregnancy, before and after pregnancy recognition.

SUBMITTER: Marshall AT 

PROVIDER: S-EPMC11383996 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature