Spatiotemporal dynamics of tumor - CAR T-cell interaction following local administration in solid cancers.

ABSTRACT: The success of chimeric antigen receptor (CAR) T-cell therapy in treating hematologic malignancies has generated widespread interest in translating this technology to solid cancers. However, issues like tumor infiltration, the immunosuppressive tumor microenvironment, and tumor heterogeneity limit its efficacy in the solid tumor setting. Recent experimental and clinical studies propose local administration directly into the tumor or at the tumor site to increase CAR T-cell infiltration and improve treatment outcomes. Characteristics of the types of solid tumors that may be the most receptive to this treatment approach remain unclear. In this work, we develop a spatiotemporal model for CAR T-cell treatment of solid tumors, and use numerical simulations to compare the effect of introducing C

SUBMITTER: Owens K 

PROVIDER: S-EPMC11384001 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature