Patterns of hormonal changes in hypophysitis by immune checkpoint inhibitor.

ABSTRACT:

Background/aims

Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events, including endocrine dysfunctions, which can have serious consequences on patient health and quality of life. The clinical course and characteristics of immune-related hypophysitis (irH) are not well established. This study aimed to analyze the clinical course and characteristics of irH.

Methods

This single-center, retrospective study analyzed data from electronic medical records of Asan Medical Center, spanning January 2017 through June 2021. It included adult patients with solid tumors who underwent thyroid and adrenal function tests, along with gonadotropin and/or growth hormone evaluations, following the initiation of ICI treatment within the same period. The study explored the c

SUBMITTER: Sang H 

PROVIDER: S-EPMC11384252 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature