Obesity is associated with incident chronic kidney disease in individuals with normal renal function.

ABSTRACT:

Background/aims

Obesity has known to be a modifiable risk factor associated with worse outcomes in chronic kidney disease (CKD), but few studies have examined the impact of obesity on CKD incidence in the general population. The purpose of this study was to investigate the role of body mass index (BMI) and waist-to-hip ratio (WHR) as predictors of incident CKD and to evaluate the impact of weight reduction on CKD prevention.

Methods

A total of 2,711 participants from a community-based cohort with normal renal function were prospectively analyzed. Among participants with obesity, we analyzed the change in WHR to evaluate the association of obesity reduction with CKD development.

Results

During a mean follow-up of 11.03 ± 4.22 years, incident CKD occurred in 190 (7.0%)

SUBMITTER: Song SH 

PROVIDER: S-EPMC11384258 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature