Changes in short-chain fatty acids affect brain development in mice with early life antibiotic-induced dysbacteriosis.

ABSTRACT:

Background

Early enteral nutrition and the gut microbiota profoundly influence neonatal brain development, with short-chain fatty acids (SCFAs) from the microbiota playing a pivotal role. Understanding the relationship between dysbiosis, SCFAs, and brain development is crucial. In this study, we investigated the impact of antibiotics on the concentration of SCFAs in neonatal feces. Additionally, we developed a model of gut dysbiosis in neonatal mice to examine the potential relationship between this imbalance, SCFAs production, and brain function development.

Methods

We measured the SCFAs content in the feces of two groups of neonates, categorized based on whether antibiotics were used, and conducted the Neonatal Behavioral Neurological Assessment (NBNA) test on all neonates

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11384438 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature