A narrative review of genes associated with liver fibrosis in biliary atresia.

ABSTRACT:

Background and objective

Biliary atresia (BA) is characterized by biliary inflammation and obstruction. In the later phase, liver fibrosis occurs. Although the etiology of BA is believed to be multi-factorial, genetic predisposition has been proposed to play a critical role in the pathogenesis. This review aimed to provide an updated summary of the genes that have been reported to be involved in BA-associated liver fibrosis.

Methods

The review was conducted via evaluation of MalaCards (BA disease: MalaCards-research articles, drugs, genes, clinical trials) which is a universally applied website including various human disease database. The database of genes that are involved in liver fibrosis were studied.

Key content and findings

Thirty-one genes that are associated

SUBMITTER: Liu F 

PROVIDER: S-EPMC11384443 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature