Effect of family history of cancer on postoperative survival in patients with non-small cell lung cancer.

ABSTRACT:

Background

Family history of cancer (FHC) has been reported to increase mortality of non-small cell lung cancer, mainly comprised of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). However, the impact of FHC on long-term survival remains controversial. This study aims to identify the impact of FHC on postoperative survival in LUAD and LUSC.

Methods

Patients underwent lung resection for LUAD or LUSC in West China Hospital from 2009 to 2021 were enrolled. The 5-year overall survival (OS), lung cancer-specific survival (LCSS) and progression-free survival (PFS) were compared between the patients with and without FHC. Multivariable Cox regression was also performed.

Results

A total of 6,253 patients were enrolled, including 5,685 LUAD and 568 LUSC. Alt

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11384475 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature