Oncogene-addicted solid tumors and microbiome-lung cancer as a main character: a narrative review.

ABSTRACT:

Background and objective

Lung cancer stands as the main cause of cancer-related deaths worldwide. With the advent of immunotherapy and the discovery of targetable oncogenic driver genes, although prognosis has changed in the last few years, survival rates remain dismal for most patients. This emphasizes the urgent need for new strategies that could enhance treatment in precision medicine. The role of the microbiota in carcinogenesis constitutes an evolving landscape of which little is known. It has been suggested these microorganisms may influence in responses, resistance, and adverse effects to cancer treatments, particularly to immune checkpoint blockers. However, evidence on the impact of microbiota composition in oncogene-addicted tumors is lacking. This review aims to provide

SUBMITTER: Guardamagna M 

PROVIDER: S-EPMC11384476 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature