Effective induction immunotherapy minimizes surgical invasiveness for locally advanced lung cancer.

ABSTRACT:

Background

Immunotherapy has been recommended for neoadjuvant therapy in patients with locally advanced non-small cell lung cancer (NSCLC). However, its effect on surgical resection has not yet been examined. This study aimed to examine the effect of induction immunotherapy on surgical resection in terms of the surgical approach, resection extent, and perioperative recovery.

Methods

We performed a real-world study comprising consecutive patients with clinical stage IB-IIIB NSCLC who received surgical resection after induction immunotherapy from January 2019 to September 2021. The perioperative outcomes were compared in terms of the surgical approach and resection extent.

Results

Among 68 patients, 37 (54.4%) achieved a clinical objective response. Standard resection w

SUBMITTER: Bao F 

PROVIDER: S-EPMC11384483 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature