Evaluation of the novel International Association for the Study of Lung Cancer grading system in adenocarcinoma with spread through air space.

ABSTRACT:

Background

The International Association for the Study of Lung Cancer (IASLC) pathology panel has proposed a new grading system for invasive lung adenocarcinoma (LADC). This study aims to validate this novel grading system for invasive LADC using propensity score matching (PSM), with a specific focus on patients exhibiting spread through air space (STAS).

Methods

We retrospectively analyzed the clinicopathologic features of a large cohort of 910 non-mucinous LADCs with STAS from 2017 to 2020 and classified them according to the novel grading system. We applied PSM to adjust for potential confounders between the grading groups. Kaplan-Meier and Cox proportional hazards models were adopted for prognostic evaluation.

Results

The results showed that the IASLC grading syst

SUBMITTER: Xu K 

PROVIDER: S-EPMC11384489 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature