Research into overcoming drug resistance in lung cancer treatment using CRISPR-Cas9 technology: a narrative review.

ABSTRACT:

Background and objective

Lung cancer remains a leading cause of cancer-related mortality globally, with drug resistance posing a significant challenge to effective treatment. The advent of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (CRISPR-Cas9) technology offers a novel and precise gene-editing technology for targeting and negating drug resistance mechanisms in lung cancer. This review summarizes the research progress in the use of CRISPR-Cas9 technology for investigating and managing drug resistance in lung cancer treatment.

Methods

A literature search was conducted using the Web of Science and PubMed databases, with the following keywords: [CRISPR-Cas9], [lung cancer], [drug resistance], [gene editing], and [gene the

SUBMITTER: Liu B 

PROVIDER: S-EPMC11384501 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature