Relationship of fibroblast growth factor 21, Klotho, and diabetic retinopathy: a meta-analysis.

ABSTRACT:

Background

Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Research has identified a close relationship between fibroblast growth factor 21 (FGF21) and DR. FGF21 is a member of the FGF subfamily, which is activated by the Klotho coenzyme involved in the occurrence of DR. However, the association between FGF21, Klotho, and DR remains controversial.

Aim

To assess FGF21 and Klotho levels in patients with DR.

Methods

A literature search of the Web of Science, Wiley Online Library, PubMed, China National Knowledge Infrastructure and Wanfang databases was performed. The title or abstract search terms "diabetic retinopathy" and "DR" were used in combination with "fibroblast growth factor 21", "FGF21", and "Klotho". Meta-analysis result

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11384578 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature