Causal relationship between immune cells and risk of myocardial infarction: evidence from a Mendelian randomization study.

ABSTRACT:

Background

Atherosclerotic plaque rupture is a major cause of heart attack. Previous studies have shown that immune cells are involved in the development of atherosclerosis, but different immune cells play different roles. The aim of this study was to investigate the causal relationship between immunological traits and myocardial infarction (MI).

Methods

To assess the causal association of immunological profiles with myocardial infarction based on publicly available genome-wide studies, we used a two-sample mendelian randomization (MR) approach with inverse variance weighted (IVW) as the main analytical method. Sensitivity analyses were used to assess heterogeneity and horizontal pleiotropy.

Results

A two-sample MR analysis was conducted using IVW as the primary metho

SUBMITTER: Cao W 

PROVIDER: S-EPMC11384581 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature