Impact of anti-fracture medications on bone material and strength properties: a systematic review and meta-analysis.

ABSTRACT:

Background and aims

Reduced bone mineral density (BMD) and microarchitectural deterioration contribute to increased fracture risk. Although the effects of anti-fracture medications (AFMs) on BMD are well-documented, their impact on bone material properties (BMPs) remains poorly characterized. Accordingly, we conducted a systematic review and meta-analysis to evaluate the effects of AFMs on BMPs. Based on data availability, we further categorized AFMs into anti-resorptives, bisphosphonates alone, and strontium ranelate subgroups to perform additional analyses of BMPs in osteoporotic patients.

Methods

We did a comprehensive search of three databases, namely, PubMed, Web of Science, and Google Scholar, using various permutation combinations, and used Comprehensive Meta-Analysis

SUBMITTER: Sharma S 

PROVIDER: S-EPMC11384599 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature