Increased plasma AACT level as an indicator of poor prognosis in patients hospitalised with community-acquired pneumonia: a multicentre prospective cohort study.

ABSTRACT:

Background and objective

Community-acquired pneumonia (CAP) is a common respiratory disease that frequently requires hospitalisation, and is a significant cause of death worldwide. This study aimed to evaluate the usefulness of alpha-1-antichymotrypsin (AACT) as a diagnostic and prognostic biomarker of CAP.

Methods

We conducted a multicentre prospective cohort study in patients hospitalised with CAP. Plasma AACT levels were measured using a quantitative enzyme-linked immunosorbent assay. Receiver-operating characteristic (ROC) curves and Cox proportional hazards regression were used to assess the association between plasma AACT levels and CAP diagnosis and prognosis.

Results

A total of 274 patients with CAP were enrolled in the study. AACT levels were elevated in pati

SUBMITTER: Zhao L 

PROVIDER: S-EPMC11384707 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature