Structural reconstruction of mouse acute aortic dissection by intravenously administered human Muse cells without immunosuppression.

ABSTRACT:

Background

Stanford type B-acute aortic dissection (type B-AAD) is often life-threatening without invasive surgery. Multilineage-differentiating stress enduring cell (Muse cells), which comprise several percent of mesenchymal stem cells (MSCs), are endogenous pluripotent-like stem cells that selectively home to damaged tissue and replace damaged/apoptotic cells by in-vivo differentiation.

Methods

Mortality, aortic diameter expansion, cell localization, cell differentiation, and inflammation of the dissected aorta were evaluated in type B-AAD model mice intravenously injected with human-Muse cells, -elastin-knockdown (KD)-Muse cells, -human leukocyte antigen-G (HLA-G)-KD-Muse cells, or MSCs, all without immunosuppressant.

Results

Here, we show the Muse (50,000 cells) g

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC11384757 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature