Development of a fully automated workstation for conducting routine SABRE hyperpolarization.

ABSTRACT: SABRE is emerging as a fast, simple and low-cost hyperpolarization method because of its ability to regenerate enhanced NMR signals. Generally, SABRE hyperpolarization has been performed predominantly manually, leading to variations in reproducibility and efficiency. Recent advances in SABRE include the development of automated shuttling systems to address previous inconsistencies. However, the operational complexity of such systems and the challenges of integration with existing workflows hinder their widespread adoption. This work presents a fully automated lab workstation based on a benchtop NMR spectrometer, specifically designed to facilitate SABRE of different nuclei across different polarization fields. We demonstrated the capability of this system through a series of routine SABRE

SUBMITTER: Yang J 

PROVIDER: S-EPMC11384770 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature