Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function.

ABSTRACT: We investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. In this cross-sectional study, 7400 community-dwelling participants underwent brain MRI and health checkups between 2016 and 2018. Hemoglobin A_1c (HbA_1c), glycated albumin (GA), homeostasis model assessment for insulin resistance (HOMA-IR), and HOMA of percent β-cell function (HOMA-β) were evaluated. The associations of each measure with a smaller volume of the hippocampus and twelve hippocampal subfields were investigated. As a result, higher HbA_1c or GA and lower HOMA-β levels were significantly associated with smaller volumes in multiple hippocampal subfields. Furthermore, even when we analyzed non-diabetic individuals,

SUBMITTER: Shima A 

PROVIDER: S-EPMC11384785 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature