PAR1-mediated Non-periodical Synchronized Calcium Oscillations in Human Mesangial Cells.

ABSTRACT: Mesangial cells offer structural support to the glomerular tuft and regulate glomerular capillary flow through their contractile capabilities. These cells undergo phenotypic changes, such as proliferation and mesangial expansion, resulting in abnormal glomerular tuft formation and reduced capillary loops. Such adaptation to the changing environment is commonly associated with various glomerular diseases, including diabetic nephropathy and glomerulonephritis. Thrombin-induced mesangial remodeling was found in diabetic patients, and expression of the corresponding protease-activated receptors (PARs) in the renal mesangium was reported. However, the functional PAR-mediated signaling in mesangial cells was not examined. This study investigated protease-activated mechanisms regulating mesangial

SUBMITTER: Stefanenko M 

PROVIDER: S-EPMC11384906 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature