A novel tumor-derived exosomal gene signature predicts prognosis in patients with pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer is a devastating disease with poor prognosis. Accumulating evidence has shown that exosomes and their cargo have the potential to mediate the progression of pancreatic cancer and are promising non-invasive biomarkers for the early detection and prognosis of this malignancy. This study aimed to construct a gene signature from tumor-derived exosomes with high prognostic capacity for pancreatic cancer using bioinformatics analysis.

Methods

Gene expression data of solid pancreatic cancer tumors and blood-derived exosome tissues were downloaded from The Cancer Genome Atlas (TCGA) and ExoRBase 2.0. Overlapping differentially expressed genes (DEGs) in the two datasets were analyzed, followed by functional enrichment analysis, protein-protein interaction

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11384923 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature