Core-size and geometry versus toxicity in small amino terminated PAMAM dendrimers.

ABSTRACT: A series of 6 small PAMAM dendrimers (G0-dendrimers) differing in the size, polarity and flexibility has been synthesized. The toxicity has been investigated in three different human cancer cell lines (HeLa, MCF-7, THP-1) and the endothelial skin cell line HMEC-1 in order to evaluate their potential as vehicles for drug delivery.

SUBMITTER: Hansen CB 

PROVIDER: S-EPMC11384932 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature