Does autoimmune diseases increase the risk of frailty? A Mendelian randomization study.

ABSTRACT:

Background

The causality of autoimmune diseases with frailty has not been firmly established. We conducted this Mendelian randomization (MR) study to unveil the causal associations between autoimmune diseases with frailty.

Methods

A MR analyses were performed to explore the relationships between autoimmune disease and frailty, using summary genome-wide association statistics.

Results

Through a comprehensive and meticulous screening process, we incorporated 46, 7, 12, 20, 5, and 53 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for hypothyroidism, hyperthyroidism, rheumatoid arthritis (RA), type 1 diabetes (T1D), multiple sclerosis (MS), and overall autoimmune disease, respectively. Our analysis revealed that hypothyroidism (OR = 1.023, 95% CI:

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11384993 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature