Meta-analysis of oral microbiome reveals sex-based diversity in biofilms during periodontitis.

ABSTRACT: Sex is an often overlooked, yet compulsory, biological variable when performing biomedical research. Periodontitis is a common yet progressively debilitating chronic inflammatory disorder affecting the tissues supporting teeth that ultimately leads to tooth loss if left untreated. The incidence of periodontitis is sex biased, with increased prevalence in males compared with females but with unknown etiology. We performed a sex-specific meta-analysis using publicly available oral microbiome data from different sampling sites of patients with periodontitis and periodontally healthy controls; sex balance was established for each periodontal health condition. Our results show sex-based diversity in oral biofilms of individuals with periodontitis but not in their saliva, with increased abundanc

SUBMITTER: Del Pinto R 

PROVIDER: S-EPMC11385077 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature