The evolution of envelope function during coinfection with phylogenetically distinct human immunodeficiency virus.

ABSTRACT:

Background

Coinfection with two phylogenetically distinct Human Immunodeficiency Virus-1 (HIV-1) variants might provide an opportunity for rapid viral expansion and the emergence of fit variants that drive disease progression. However, autologous neutralising immune responses are known to drive Envelope (Env) diversity which can either enhance replicative capacity, have no effect, or reduce viral fitness. This study investigated whether in vivo outgrowth of coinfecting variants was linked to pseudovirus and infectious molecular clones' infectivity to determine whether diversification resulted in more fit virus with the potential to increase disease progression.

Results

For most participants, emergent recombinants displaced the co-transmitted variants and comprised the major

SUBMITTER: Omar S 

PROVIDER: S-EPMC11385138 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature