Carotid artery vascular stenosis causes the blood-CSF barrier damage and neuroinflammation.

ABSTRACT:

Background

The choroid plexus (ChP) helps maintain the homeostasis of the brain by forming the blood-CSF barrier via tight junctions (TJ) at the choroid plexus epithelial cells, and subsequently preventing neuroinflammation by restricting immune cells infiltration into the central nervous system. However, whether chronic cerebral hypoperfusion causes ChP structural damage and blood-CSF barrier impairment remains understudied.

Methods

The bilateral carotid stenosis (BCAS) model in adult male C57BL/6 J mice was used to induce cerebral hypoperfusion, a model for vascular contributions to cognitive impairment and dementia (VCID). BCAS-mediated changes of the blood-CSF barrier TJ proteins, apical secretory Na⁺-K⁺-Cl^- cotransporter isoform 1 (NKCC1

SUBMITTER: Lin L 

PROVIDER: S-EPMC11385148 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature