Oral inoculation of <i>Fusobacterium nucleatum</i> exacerbates ulcerative colitis via the secretion of virulence adhesin FadA.

ABSTRACT: Fusobacterium nucleatum (F. nucleatum), an anaerobic resident of the oral cavity, is increasingly recognized as a contributing factor to ulcerative colitis (UC). The adhesive properties of F. nucleatum are mediated by its key virulence protein, FadA adhesin. However, further investigations are needed to understand the pathogenic mechanisms of this oral pathogen in UC. The present study aimed to explore the role of the FadA adhesin in the colonization and invasion of oral F. nucleatum in dextran sulphate sodium (DSS)-induced colitis mice via molecular techniques. In this study, we found that oral inoculation of F. nucleatum strain carrying the FadA adhesin further exacerbated DSS-induced colitis, leading to elevated alveolar bone loss, disease severity, an

SUBMITTER: Li D 

PROVIDER: S-EPMC11385161 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature