Lipidomics profiling and circulating triglyceride concentrations in sub-Saharan African individuals.

ABSTRACT: Elevated triglycerides (TG) are a risk factor for cardiometabolic disorders. There are limited data on lipidomics profiles associated with serum triglycerides concentrations, although these could advance our understanding of the mechanisms underlying these associations. We conducted a lipidomics study of 308 Nigerians with replication in 199 Kenyans. Regression models were used to assess the association of TG with 480 lipid metabolites. Association and mediation analyses were conducted to determine the relationship among TG, metabolites, and several cardiometabolic traits. Ninety-nine metabolites were significantly associated with TG, and 91% of these associations replicated. Overrepresentation analysis identified enrichment of diacylglycerols, monoacylglycerols, diacylglycerophosphoethano

SUBMITTER: Bentley AR 

PROVIDER: S-EPMC11385232 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature