Different polarization and functionality of CD4+ T helper subsets in people with post-COVID condition.

ABSTRACT:

Introduction

After mild COVID-19 that does not require hospitalization, some individuals develop persistent symptoms that may worsen over time, producing a multisystemic condition termed Post-COVID condition (PCC). Among other disorders, PCC is characterized by persistent changes in the immune system that may not be solved several months after COVID-19 diagnosis.

Methods

People with PCC were recruited to determine the distribution and functionality of CD4+ T helper (Th) subsets in comparison with individuals with mild, severe, and critical presentations of acute COVID-19 to evaluate their contribution as risk or protective factors for PCC.

Results

People with PCC showed low levels of Th1 cells, similar to individuals with severe and critical COVID-19, although these c

SUBMITTER: Sanchez-Menendez C 

PROVIDER: S-EPMC11385313 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature