Lineage-based scaling of germline intercellular bridges during oogenesis.

ABSTRACT: The size of subcellular structures must be tightly controlled to maintain normal cell function. Despite its importance, few studies have determined how the size of organelles or other structures is maintained during development, when cells are growing, dividing and rearranging. The developing Drosophila egg chamber is a powerful model in which to study the relative growth rates of subcellular structures. The egg chamber contains a cluster of 16 germline cells, which are connected through intercellular bridges called ring canals. As the egg chamber grows, the germline cells and the ring canals that connect them increase in size. Here, we demonstrate that ring canal size scaling is related to lineage; the largest, 'first-born' ring canals increase in size at a relatively slower rate than rin

SUBMITTER: Shaikh U 

PROVIDER: S-EPMC11385318 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature