Lactated Ringer vs Normal Saline Solution During Sickle Cell Vaso-Occlusive Episodes.

ABSTRACT:

Importance

Sickle cell disease (SCD), a clinically heterogenous genetic hemoglobinopathy, is characterized by painful vaso-occlusive episodes (VOEs) that can require hospitalization. Patients admitted with VOEs are often initially resuscitated with normal saline (NS) to improve concurrent hypovolemia, despite preclinical evidence that NS may promote erythrocyte sickling. The comparative effectiveness of alternative volume-expanding fluids (eg, lactated Ringer [LR]) for resuscitation during VOEs is unclear.

Objective

To compare the effectiveness of LR to NS fluid resuscitation in patients with SCD and VOEs.

Design, setting, and participants

This multicenter cohort study and target trial emulation included inpatient adults with SCD VOEs who received either LR or NS on h

SUBMITTER: Alwang AK 

PROVIDER: S-EPMC11385329 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature