Genetic heterogeneity in the <i>Salmonella</i> Typhi Vi capsule locus: a population genomic study from Fiji.

ABSTRACT: Typhoid fever is endemic in many parts of the world and remains a major public health concern in tropical and sub-tropical developing nations, including Fiji. To address high rates of typhoid fever, the Northern Division of Fiji implemented a mass vaccination with typhoid conjugate vaccine (Vi-polysaccharide conjugated to tetanus toxoid) as a public health control measure in 2023. In this study we define the genomic epidemiology of Salmonella Typhi in the Northern Division prior to island-wide vaccination, sequencing 85% (n=419) of the total cases from the Northern and Central Divisions of Fiji that occurred in the period 2017-2019. We found elevated rates of nucleotide polymorphisms in the tviD and tviE genes (responsible for Vi-polysaccharide synthesis) relati

SUBMITTER: Getahun Strobel A 

PROVIDER: S-EPMC11385387 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature