Integrated Long Noncoding RNA and Messenger RNA Expression Analysis Identifies Molecules Specifically Associated With Resiliency and Susceptibility to Depression and Antidepressant Response.

ABSTRACT:

Background

Depression involves maladaptive processes impairing an individual's ability to interface with the environment appropriately. Long noncoding RNAs (lncRNAs) are gaining traction for their role in higher-order brain functioning. Recently, we reported that lncRNA coexpression modules may underlie abnormal responses to stress in rats showing depression-like behavior. The current study explored the global expression regulation of lncRNAs and messenger RNAs (mRNAs) in the hippocampus of rats showing susceptibility (learned helplessness [LH]) or resiliency (non-LH) to depression and fluoxetine response to LH (LH+FLX).

Methods

Multiple comparison analysis was performed with an analysis of variance via the aov and summary function in the R platform to identify

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11385423 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature