Personality vulnerability to depression, resilience, and depressive symptoms: epigenetic markers among perinatal women.

ABSTRACT:

Background

We examined differences in DNA methylation patterns in the NR3C1 and FKBP5 genes in relation to personality vulnerability to depression, resilience, and perinatal depressive symptoms, whilst also considering possible moderating effects of childhood traumatic events.

Methods

N = 160 perinatal women were assessed at late pregnancy and 1 year postpartum for personality vulnerability to depression, resilience, depressive symptoms, and childhood traumatic events with self-reported questionnaires. NR3C1 and FKBP5 methylation markers were analyzed via sodium bisulfite sequencing. Associations of methylation markers with the above mentioned variables were tested using multivariable regressions.

Results

NR3C1 methylation at

SUBMITTER: Castro RTA 

PROVIDER: S-EPMC11385460 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature