TSPAN1 overexpression as an indicator of poor prognosis in estrogen receptor-positive breast cancer.

ABSTRACT:

Background

Tetraspanin 1 (TSPAN1) is a newly discovered protein of the tetrameric protein family encoded by the TSPAN1 gene localized in the 1p34 chromosome region. TSPAN1 has been shown to be associated with various malignancies. In this study, we aimed to investigate the prognostic significance of TSPAN1 in breast cancer. Estrogen receptor-positive (ER+) breast cancer is the largest breast cancer subgroup, and ER-targeted therapies have significantly prolonged survival and improved symptoms in advanced breast cancer. TSPAN1 overexpression was found to be associated with a poor prognosis in ER+ breast cancer.

Methods

We analyzed the expression of TSPAN1 in breast cancer tissues and cell lines using western blotting and quantitative reverse transcription polymerase ch

SUBMITTER: Liu X 

PROVIDER: S-EPMC11385530 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature