Significance of novel PANoptosis genes to predict prognosis and therapy effect in the lung adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) is the dominant histotype of non-small cell lung cancer. Panoptosis, a comprehensive form of programmed cell death, is central to carcinogenesis. In this study, the expression of PANoptosis-related genes (PRGs) and their impact on the development, prognosis, tumor microenvironment, and treatment response of patients with lung adenocarcinoma (LUAD) were systematically evaluated. PRGs were selected from The Cancer Genome Atlas database and Genecards dataset using differential expression analysis. The signature of included PRGs was identified using univariate Cox regression analysis and LASSO regression analysis. Additionally, a nomogram was developed that includes signature and clinical information. Kaplan-Meier survival analysis and receiver operating characterist

SUBMITTER: Miao Z 

PROVIDER: S-EPMC11385570 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature