Plasma metabolites as potential markers and targets to prevent and treat urolithiasis: a Mendelian randomization study.

ABSTRACT:

Background

Studies on the relationships between diseases of the urinary system and human plasma proteomes have identified several potential biomarkers. However, none of these studies have elucidated the causal relationships between plasma proteins and urolithiasis.

Objective

The objective of the study was to investigate the potential risks of plasma metabolites in urolithiasis using a two-sample Mendelian randomization (MR) study.

Methods

A total of 1,400 metabolites were identified in the most comprehensive genome-wide association study (GWAS) of plasma metabolomics in a European population to date, and single-nucleotide polymorphisms (SNPs) were used as the instrumental variables for the plasma metabolites. The European GWAS data for urinary calculi included 482,123

SUBMITTER: Zhu W 

PROVIDER: S-EPMC11385617 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature