Developmental analysis of Spalt function in the Drosophila prothoracic gland.

ABSTRACT: The Spalt transcriptional regulators participate in a variety of cell fate specification processes during development, regulating transcription through interactions with DNA AT-rich regions. Spalt proteins also bind to heterochromatic regions, and some of their effects require interactions with the NuRD chromatin remodeling and deacetylase complex. Most of the biological roles of Spalt proteins have been characterized in diploid cells engaged in cell proliferation. Here, we address the function of Drosophila Spalt genes in the development of a larval tissue formed by polyploid cells, the prothoracic gland, the cells of which undergo several rounds of DNA replication without mitosis during larval development. We show that prothoracic glands depleted of Spalt expression display severe change

SUBMITTER: Ostale CM 

PROVIDER: S-EPMC11385645 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature