Synthesis of ferrocenyl benzimidazole derivatives as novel anti-Toxoplasma gondii agents.

ABSTRACT: Toxoplasmosis, a disease caused by the apicomplexan parasite Toxoplasma gondii, affects up to one third of the global population. Although immunocompetent individuals rarely experience severe symptoms, those with immunodeficiencies may potentially face fatal disease. The frontline treatments are currently sulphadiazine and pyrimethamine, which suffer from adverse side effects, and lack efficiency in clearing parasite cysts from the muscles and brain of patients. To address the need for novel, more effective, and less toxic treatments, four new ferrocenyl benzimidazole complexes 15-18 were synthesised and evaluated against the ΔKu80:mNeonGreen strain of T. gondii. Complexes 15 and 17 were found to be active with EC₅₀ values of 17.9 and 17.5 μM respectively, with com

SUBMITTER: Ndlovu MT 

PROVIDER: S-EPMC11385693 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature