Associations between gut microbiota and osteoporosis or osteopenia in a cohort of Chinese Han youth.

ABSTRACT: Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass and microstructural deterioration of bone. Changes in the composition and structure of gut microbiota (GM) are related to changes of bone mass and bone microstructure. However, the relationship between GM and bone mineral density (BMD) is complex, and data are especially scarce for Chinese Han youth. Therefore, 62 Chinese Han youth participants were recruited. Furthermore, according to the T-score evaluation criteria of the World Health Organization (WHO), we divided the BMD levels of participants into three groups: osteoporosis\BDL, osteopenia\BDM, normal bone density\BDH, and the associations between GM community and BMD groups were conducted. According to alpha and beta diversity analysis, significant di

SUBMITTER: Lai J 

PROVIDER: S-EPMC11385745 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature