Recovery of ventilatory and metabolic responses to hypoxia in neonatal rats after chronic hypoxia.

ABSTRACT: Chronic hypoxia (CH) during postnatal development attenuates the hypoxic ventilatory response (HVR) in mammals, but there are conflicting reports on whether this plasticity is permanent or reversible. This study tested the hypothesis that CH-induced respiratory plasticity is reversible in neonatal rats and investigated whether the initial plasticity or recovery differs between sexes. Rat pups were exposed to 3 d of normobaric CH (12 % O₂) beginning shortly after birth. Ventilation and metabolic CO₂ production were then measured in normoxia and during an acute hypoxic challenge (12 % O₂) immediately following CH and after 1, 4-5, and 7 d in room air. CH pups hyperventilated when returned to normoxia immediately following CH, but normoxic ventilation was simi

SUBMITTER: Bavis RW 

PROVIDER: S-EPMC11385746 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature